منابع مشابه
On the overdispersed molecular clock.
Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuating substitution rates in time caused by coupled effects of deleterious mutatio...
متن کاملUnderstanding the overdispersed molecular clock.
Rates of molecular evolution at some protein-encoding loci are more irregular than expected under a simple neutral model of molecular evolution. This pattern of excessive irregularity in protein substitutions is often called the "overdispersed molecular clock" and is characterized by an index of dispersion, R(T) > 1. Assuming infinite sites, no recombination model of the gene R(T) is given for ...
متن کاملWith the correct concept of mutation rate, cluster mutations can explain the overdispersed molecular clock.
IN his response to our article (Huai and Woodruff and H. Huai, unpublished results). Our understanding of the substitution process critically depends on treat1997), Cutler takes it for granted that mutation rate and mutational event rate are the same in multiment of the complexity of the mutational process. From its earliest definition, the term “mutation rate” cellular species, but there is fu...
متن کاملClusters of identical new mutations can not account for the "overdispersed" molecular clock.
Germ-cell mutations may occur during meiosis, giving rise to independent mutant gametes in a Poisson process, or before meiosis, giving rise to multiple copies of identical mutant gametes at a much higher probability than the Poisson expectation. We report that the occurrence of these early premeiotic clusters of new identical mutant alleles increases the variance-to-mean ratio of mutation rate...
متن کاملEstimating divergence times in the presence of an overdispersed molecular clock.
Molecular loci that fail relative-rate tests are said to be "overdispersed." Traditional molecular-clock approaches to estimating divergence times do not take this into account. In this study, a method was developed to estimate divergence times using loci that may be overdispersed. The approach was to replace the traditional Poisson process assumption with a more general stationary process assu...
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ژورنال
عنوان ژورنال: Genetics
سال: 1987
ISSN: 1943-2631
DOI: 10.1093/genetics/116.1.169